Curated Information
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Curated Information Page
PubMed Id: 15308649 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wagner LE, Li WH, Joseph SK, Yule DI (2004) Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor. J Biol Chem 279, 46242-52 15308649
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1589-p - IP3R1 (rat)
Orthologous residues
IP3R1 (human): S1598‑p, IP3R1 iso3 (human): S1589‑p, IP3R1 (mouse): S1588‑p, IP3R1 iso2 (mouse): S1573‑p, IP3R1 (rat): S1589‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.

S1756-p - IP3R1 (rat)
Orthologous residues
IP3R1 (human): S1764‑p, IP3R1 iso3 (human): S1716‑p, IP3R1 (mouse): S1755‑p, IP3R1 iso2 (mouse): S1740‑p, IP3R1 (rat): S1756‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial), DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.


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