Curated Information

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Curated Information Page

PubMed Id: 15308649

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Wagner LE, Li WH, Joseph SK, Yule DI (2004) Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor. J Biol Chem 279, 46242-52 15308649

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S1589-p - IP3R1 (rat)

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Orthologous residues

IP3R1 (human): S1598‑p, IP3R1 iso3 (human): S1589‑p, IP3R1 (mouse): S1588‑p, IP3R1 iso2 (mouse): S1573‑p, IP3R1 (rat): S1589‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 293 (epithelial), DT40 (B lymphocyte)

Cellular systems studied: cell lines

Species studied: chicken, human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
forskolin				increase

Downstream Regulation

Effect of modification (function): activation

Comments: Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.

S1756-p - IP3R1 (rat)

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