Curated Information
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Curated Information Page
PubMed Id: 15451423 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Itakura E, et al. (2004) ATR-dependent phosphorylation of ATRIP in response to genotoxic stress. Biochem Biophys Res Commun 323, 1197-202 15451423
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S68-p - ATRIP (human) ▲
Orthologous residues
ATRIP (human): S68‑p, ATRIP iso2 (human): S68‑p, ATRIP (mouse): S69‑p, ATRIP (rat): S69‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  A549 (pulmonary) [ATRIP (human)], HeLa (cervical) [ATR (human)], HeLa (cervical) [ATRIP (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE ATR (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATR (human) transfection of inactive enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hydroxyurea increase
UV increase
Downstream Regulation
 Effect of modification (function):  intracellular localization

S72-p - ATRIP (human) ▲
Orthologous residues
ATRIP (human): S72‑p, ATRIP iso2 (human): S72‑p, ATRIP (mouse): S73‑p, ATRIP (rat): S73‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  A549 (pulmonary) [ATRIP (human)], HeLa (cervical) [ATR (human)], HeLa (cervical) [ATRIP (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE ATR (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATR (human) transfection of inactive enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hydroxyurea increase
UV increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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