Curated Information
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Curated Information Page
PubMed Id: 15451423 
Itakura E, et al. (2004) ATR-dependent phosphorylation of ATRIP in response to genotoxic stress. Biochem Biophys Res Commun 323, 1197-202 15451423
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S68-p - ATRIP (human)
Orthologous residues
ATRIP (human): S68‑p, ATRIP iso2 (human): S68‑p, ATRIP (mouse): S69‑p, ATRIP (rat): S69‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  A549 (pulmonary) [ATRIP (human)], HeLa (cervical) [ATR (human)], HeLa (cervical) [ATRIP (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATR (human) transfection of inactive enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hydroxyurea increase
UV increase
Downstream Regulation
 Effect of modification (function):  intracellular localization

S72-p - ATRIP (human)
Orthologous residues
ATRIP (human): S72‑p, ATRIP iso2 (human): S72‑p, ATRIP (mouse): S73‑p, ATRIP (rat): S73‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  A549 (pulmonary) [ATRIP (human)], HeLa (cervical) [ATR (human)], HeLa (cervical) [ATRIP (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATR (human) transfection of inactive enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hydroxyurea increase
UV increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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