Curated Information
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Curated Information Page
PubMed Id: 18463240 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cheung ZH, Gong K, Ip NY (2008) Cyclin-dependent kinase 5 supports neuronal survival through phosphorylation of Bcl-2. J Neurosci 28, 4872-7 18463240
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S70-p - Bcl-2 (mouse)
Orthologous residues
Bcl‑2 (human): S70‑p, Bcl‑2 (mouse): S70‑p, Bcl‑2 (rat): S70‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, retina
 Cellular systems studied:  primary cells, tissue
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK5 (mouse) phospho-motif antibody, co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, modification site within consensus motif, microscopy-colocalization
Downstream Regulation
 Effect of modification (process):  apoptosis, inhibited


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