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Orthologous residues
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Bcl‑2 (human): S70‑p, Bcl‑2 (mouse): S70‑p, Bcl‑2 (rat): S70‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody, western blotting
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|
Relevant cell lines - cell types - tissues:
brain, retina
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Cellular systems studied:
primary cells, tissue
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Species studied:
mouse
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Enzymes shown to modify site in vitro:
|
|
|
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Upstream Regulation
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|
Potential in vivo enzymes for site:
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|
Type
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Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
CDK5 (mouse)
|
phospho-motif antibody, modification site within consensus motif, co-immunoprecipitation, microscopy-colocalization, genetic knockout/knockin of upstream enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
apoptosis, inhibited
|
