Curated Information
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PubMed Id: 15475459 
Hov H, et al. (2004) A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells. Clin Cancer Res 10, 6686-94 15475459
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1003-p - Met (human)
Orthologous residues
Met (human): Y1003‑p, Met (mouse): Y1001‑p, Met (rat): Y1004‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  multiple myeloma
 Relevant cell lines - cell types - tissues:  INA-6 (B lymphocyte)
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase

Y1230-p - Met (human)
Orthologous residues
Met (human): Y1230‑p, Met (mouse): Y1228‑p, Met (rat): Y1231‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  multiple myeloma
 Relevant cell lines - cell types - tissues:  INA-6 (B lymphocyte)
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase

Y1234-p - Met (human)
Orthologous residues
Met (human): Y1234‑p, Met (mouse): Y1232‑p, Met (rat): Y1235‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  multiple myeloma
 Relevant cell lines - cell types - tissues:  INA-6 (B lymphocyte)
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase

Y1235-p - Met (human)
Orthologous residues
Met (human): Y1235‑p, Met (mouse): Y1233‑p, Met (rat): Y1236‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  multiple myeloma
 Relevant cell lines - cell types - tissues:  INA-6 (B lymphocyte)
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase

Y1349-p - Met (human)
Orthologous residues
Met (human): Y1349‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  multiple myeloma
 Relevant cell lines - cell types - tissues:  INA-6 (B lymphocyte)
 Cellular systems studied:  cell lines
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
HGF increase
PHA-665752 HGF inhibit treatment-induced increase


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