Curated Information
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Curated Information Page
PubMed Id: 12374799 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Xu BE, et al. (2002) Regulation of WNK1 by an autoinhibitory domain and autophosphorylation. J Biol Chem 277, 48456-62 12374799
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S378-p - WNK1 (rat) ▲
Orthologous residues
WNK1 (human): S378‑p, WNK1 iso4 (human): S378‑p, WNK1 (mouse): S378‑p, WNK1 iso3 (mouse): S378‑p, WNK1 iso8 (mouse): ‑, WNK1 (rat): S378‑p
Characterization
 Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE WNK1 (rat)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hypertonic buffer increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

S382-p - WNK1 (rat) ▲
Orthologous residues
WNK1 (human): S382‑p, WNK1 iso4 (human): S382‑p, WNK1 (mouse): S382‑p, WNK1 iso3 (mouse): S382‑p, WNK1 iso8 (mouse): ‑, WNK1 (rat): S382‑p
Characterization
 Methods used to characterize site in vivo:  electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE WNK1 (rat)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hypertonic buffer increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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