Curated Information
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Curated Information Page
PubMed Id: 18322105 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wen Y, et al. (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28, 2624-32 18322105
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S473-p - Akt1 (human) ▲
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
CI-1033 EGF inhibit treatment-induced increase
CI-1033 decrease

S9-p - GSK3B (human) ▲
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  SH-SY5Y (neural crest)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
CI-1033 EGF inhibit treatment-induced increase
CI-1033 decrease

S473-p - Akt1 (mouse) ▲
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5 (mouse) decrease homozygous null
CDK5R1 (mouse) increase
CI-1033 CDK5R1 (mouse) inhibit treatment-induced increase

S33-p - CTNNB1 (mouse) ▲
Orthologous residues
CTNNB1 (human): S33‑p, CTNNB1 (mouse): S33‑p, CTNNB1 (rat): S33‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) decrease

S37-p - CTNNB1 (mouse) ▲
Orthologous residues
CTNNB1 (human): S37‑p, CTNNB1 (mouse): S37‑p, CTNNB1 (rat): S37‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) decrease

T41-p - CTNNB1 (mouse) ▲
Orthologous residues
CTNNB1 (human): T41‑p, CTNNB1 (mouse): T41‑p, CTNNB1 (rat): T41‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) decrease

S9-p - GSK3B (mouse) ▲
Orthologous residues
GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) increase
CI-1033 CDK5R1 (mouse) inhibit treatment-induced increase
CP-681301 CDK5R1 (mouse) inhibit treatment-induced increase
CDK5 (mouse) decrease homozygous null

Y878-p - HER2 (mouse) ▲
Orthologous residues
HER2 (human): Y877‑p, HER2 iso2 (human): Y267‑p, HER2 (mouse): Y878‑p, HER2 (rat): Y879‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) increase
CDK5 (mouse) decrease homozygous null

Y199-p - PIK3R3 (mouse) ▲
Orthologous residues
PIK3R3 (human): Y199‑p, PIK3R3 (mouse): Y199‑p, PIK3R3 (rat): Y199‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) increase
CDK5 (mouse) decrease homozygous null

T473-p - tau (mouse) ▲
Orthologous residues
tau (human): T498‑p, tau iso2 (human): T123‑p, tau iso3 (human): T87‑p, tau iso5 (human): T181‑p, tau iso6 (human): T123‑p, tau iso8 (human): T181‑p, tau (mouse): T473‑p, tau iso3 (mouse): T170‑p, tau iso7 (mouse): T112‑p, tau (rat): T492‑p, tau (cow): T172‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) no change compared to control

S491-p - tau (mouse) ▲
Orthologous residues
tau (human): S516‑p, tau iso2 (human): S141‑p, tau iso3 (human): S105‑p, tau iso5 (human): S199‑p, tau iso6 (human): S141‑p, tau iso8 (human): S199‑p, tau (mouse): S491‑p, tau iso3 (mouse): S188‑p, tau iso7 (mouse): S148‑p, tau (rat): S510‑p, tau (cow): S206‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) decrease
CP-681301 CDK5R1 (mouse) inhibit treatment-induced decrease

S494-p - tau (mouse) ▲
Orthologous residues
tau (human): S519‑p, tau iso2 (human): S144‑p, tau iso3 (human): S108‑p, tau iso5 (human): S202‑p, tau iso6 (human): S144‑p, tau iso8 (human): S202‑p, tau (mouse): S494‑p, tau iso3 (mouse): S191‑p, tau iso7 (mouse): S151‑p, tau (rat): S513‑p, tau (cow): S209‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) no change compared to control

T497-p - tau (mouse) ▲
Orthologous residues
tau (human): T522‑p, tau iso2 (human): T147‑p, tau iso3 (human): T111‑p, tau iso5 (human): T205‑p, tau iso6 (human): T147‑p, tau iso8 (human): T205‑p, tau (mouse): T497‑p, tau iso3 (mouse): T194‑p, tau iso7 (mouse): T154‑p, tau (rat): T516‑p, tau (cow): T212‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) increase

T523-p - tau (mouse) ▲
Orthologous residues
tau (human): T548‑p, tau iso2 (human): T173‑p, tau iso3 (human): T137‑p, tau iso5 (human): T231‑p, tau iso6 (human): T173‑p, tau iso8 (human): T231‑p, tau (mouse): T523‑p, tau iso3 (mouse): T220‑p, tau iso7 (mouse): T180‑p, tau (rat): T542‑p, tau (cow): T238‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) no change compared to control

S527-p - tau (mouse) ▲
Orthologous residues
tau (human): S552‑p, tau iso2 (human): S177‑p, tau iso3 (human): S141‑p, tau iso5 (human): S235‑p, tau iso6 (human): S177‑p, tau iso8 (human): S235‑p, tau (mouse): S527‑p, tau iso3 (mouse): S224‑p, tau iso7 (mouse): S184‑p, tau (rat): S546‑p, tau (cow): S242‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) increase
CP-681301 CDK5R1 (mouse) inhibit treatment-induced increase

S688-p - tau (mouse) ▲
Orthologous residues
tau (human): S713‑p, tau iso2 (human): S307‑p, tau iso3 (human): S271‑p, tau iso5 (human): S365‑p, tau iso6 (human): S338‑p, tau iso8 (human): S396‑p, tau (mouse): S688‑p, tau iso3 (mouse): S385‑p, tau iso7 (mouse): S345‑p, tau (rat): S707‑p, tau (cow): S403‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) no change compared to control

S696-p - tau (mouse) ▲
Orthologous residues
tau (human): S721‑p, tau iso2 (human): S315‑p, tau iso3 (human): S279‑p, tau iso5 (human): S373‑p, tau iso6 (human): S346‑p, tau iso8 (human): S404‑p, tau (mouse): S696‑p, tau iso3 (mouse): S393‑p, tau iso7 (mouse): S353‑p, tau (rat): S715‑p, tau (cow): S411‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  brain, brain [CDK5R1 (mouse)]
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CDK5R1 (mouse) no change compared to control


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