Curated Information

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Curated Information Page

PubMed Id: 11742982

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Debonneville C, et al. (2001) Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J 20, 7052-9 11742982

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S342-p - NEDD4L (human)

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Orthologous residues

NEDD4L (human): S342‑p, NEDD4L iso5 (human): S342‑p, NEDD4L (mouse): S371‑p, NEDD4L iso3 (mouse): S371‑p, NEDD4L (rat): S330‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, mutation of modification site

Relevant cell lines - cell types - tissues: oocyte [CPEB (mouse)]

Cellular systems studied: primary cells

Species studied: frog

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	SGK1 (human)	transfection of inactive enzyme, modification site within consensus motif, transfection of wild-type enzyme

Downstream Regulation

Effect of modification (function): molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
ENaC-beta (human)		Disrupts	intracellular localization		co-immunoprecipitation

S448-p - NEDD4L (human)

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