Curated Information
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Curated Information Page
PubMed Id: 11742982 
Debonneville C, et al. (2001) Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J 20, 7052-9 11742982
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S342-p - NEDD4L (human)
Orthologous residues
NEDD4L (human): S342‑p, NEDD4L iso5 (human): S342‑p, NEDD4L (mouse): S371‑p, NEDD4L iso3 (mouse): S371‑p, NEDD4L (rat): S330‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte [CPEB (mouse)]
 Cellular systems studied:  primary cells
 Species studied:  frog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE SGK1 (human) transfection of inactive enzyme, transfection of wild-type enzyme, modification site within consensus motif
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ENaC-beta (human) Disrupts intracellular localization co-immunoprecipitation

S448-p - NEDD4L (human)
Orthologous residues
NEDD4L (human): S448‑p, NEDD4L iso5 (human): S428‑p, NEDD4L (mouse): S477‑p, NEDD4L iso3 (mouse): S457‑p, NEDD4L (rat): S436‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  oocyte [CPEB (mouse)]
 Cellular systems studied:  primary cells
 Species studied:  frog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE SGK1 (human) transfection of inactive enzyme, transfection of wild-type enzyme, modification site within consensus motif
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ENaC-beta (human) Disrupts intracellular localization co-immunoprecipitation


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