Curated Information
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Curated Information Page
PubMed Id: 15342917 
Roux PP, et al. (2004) Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A 101, 13489-94 15342917
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S939-p - TSC2 (human)
Orthologous residues
TSC2 (human): S939‑p, TSC2 iso3 (human): S939‑p, TSC2 iso4 (human): S939‑p, TSC2 (mouse): S939‑p, TSC2 iso6 (mouse): S939‑p, TSC2 (rat): S939‑p, TSC2 iso2 (rat): S939‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC1 (human)], 293 (epithelial) [TSC2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
insulin increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S981-p - TSC2 (human)
Orthologous residues
TSC2 (human): S981‑p, TSC2 iso3 (human): , TSC2 iso4 (human): S981‑p, TSC2 (mouse): S981‑p, TSC2 iso6 (mouse): S981‑p, TSC2 (rat): S981‑p, TSC2 iso2 (rat):
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC1 (human)], 293 (epithelial) [TSC2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase

S1420-p - TSC2 (human)
Orthologous residues
TSC2 (human): S1420‑p, TSC2 iso3 (human): S1376‑p, TSC2 iso4 (human): S1397‑p, TSC2 (mouse): S1421‑p, TSC2 iso6 (mouse): S1399‑p, TSC2 (rat): S1422‑p, TSC2 iso2 (rat): S1379‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC1 (human)], 293 (epithelial) [TSC2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase

T1462-p - TSC2 (human)
Orthologous residues
TSC2 (human): T1462‑p, TSC2 iso3 (human): T1418‑p, TSC2 iso4 (human): T1439‑p, TSC2 (mouse): T1465‑p, TSC2 iso6 (mouse): T1443‑p, TSC2 (rat): T1466‑p, TSC2 iso2 (rat): T1423‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC1 (human)], 293 (epithelial) [TSC2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
insulin increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited

S1798-p - TSC2 (human)
Orthologous residues
TSC2 (human): S1798‑p, TSC2 iso3 (human): S1754‑p, TSC2 iso4 (human): S1775‑p, TSC2 (mouse): S1805‑p, TSC2 iso6 (mouse): S1777‑p, TSC2 (rat): S1800‑p, TSC2 iso2 (rat): S1757‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry
 Relevant cell lines - cell types - tissues:  293 (epithelial) [TSC1 (human)], 293 (epithelial) [TSC2 (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE p90RSK (human) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
Downstream Regulation
 Effect of modification (function):  activity, inhibited


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