Curated Information
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Curated Information Page
PubMed Id: 15342783 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Tomar A, et al. (2004) Regulation of cell motility by tyrosine phosphorylated villin. Mol Biol Cell 15, 4807-17 15342783
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y60-p - villin (human) ▲
Orthologous residues
villin (human): Y60‑p, villin (mouse): Y60‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [villin (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ACTB (human) Induces intracellular localization, protein conformation microscopy-colocalization
 Comments:  this site is involved in the actin skeleton remodeling and cell migration

Y81-p - villin (human) ▲
Orthologous residues
villin (human): Y81‑p, villin (mouse): Y81‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [villin (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ACTB (human) Induces intracellular localization, protein conformation microscopy-colocalization
 Comments:  this site is involved in the actin skeleton remodeling and cell migration

Y256-p - villin (human) ▲
Orthologous residues
villin (human): Y256‑p, villin (mouse): Y256‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical) [villin (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ACTB (human) Induces intracellular localization, protein conformation microscopy-colocalization
 Comments:  this site is involved in the actin skeleton remodeling and cell migration


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