Curated Information
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Curated Information Page
PubMed Id: 15240807 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hayashi T, Huganir RL (2004) Tyrosine phosphorylation and regulation of the AMPA receptor by SRC family tyrosine kinases. J Neurosci 24, 6152-60 15240807
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y876-p - GluR2 (mouse) ▲
Orthologous residues
GluR2 (human): Y876‑p, GluR2 iso2 (human): Y876‑p, GluR2 (mouse): Y876‑p, GluR2 iso3 (mouse): ‑, GluR2 (rat): Y876‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [GluR2 (mouse)], 293T (epithelial) [Lyn (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Lyn (human) transfection of inactive enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation

Y876-p - GluR2 (rat) ▲
Orthologous residues
GluR2 (human): Y876‑p, GluR2 iso2 (human): Y876‑p, GluR2 (mouse): Y876‑p, GluR2 iso3 (mouse): ‑, GluR2 (rat): Y876‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain [GluR2 (mouse)]
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
glutamate GluR2 (mouse) increase
AMPA GluR2 (mouse) increase
NMDA GluR2 (mouse) increase
Downstream Regulation
 Effect of modification (function):  receptor internalization, altered


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