Curated Information
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Curated Information Page
PubMed Id: 9295322 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Roth A, Kreienkamp HJ, Meyerhof W, Richter D (1997) Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization. J Biol Chem 272, 23769-74 9295322
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S341-p - SSTR3 (rat)
Orthologous residues
SSTR3 (human): S332‑p, SSTR3 (mouse): S341‑p, SSTR3 (rat): S341‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S346-p - SSTR3 (rat)
Orthologous residues
SSTR3 (human): S337‑p, SSTR3 (mouse): S346‑p, SSTR3 (rat): S346‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

S351-p - SSTR3 (rat)
Orthologous residues
SSTR3 (human): V342‑p, SSTR3 (mouse): S351‑p, SSTR3 (rat): S351‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
 Effect of modification (function):  receptor desensitization, altered, receptor internalization, altered

T357-p - SSTR3 (rat)
Orthologous residues
SSTR3 (human): T348‑p, SSTR3 (mouse): T357‑p, SSTR3 (rat): T357‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SST14 increase
Downstream Regulation
 Effect of modification (function):  receptor internalization, altered


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