Curated Information
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Curated Information Page
PubMed Id: 18757828 
Snabaitis AK, Cuello F, Avkiran M (2008) Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1. Circ Res 103, 881-90 18757828
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S648-p - NHE1 (human)
Orthologous residues
NHE1 (human): S648‑p, NHE1 (mouse): S652‑p, NHE1 (rat): S652‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  activity, inhibited, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Calmodulin (human) Disrupts far-Western

S703-p - NHE1 (human)
Orthologous residues
NHE1 (human): S703‑p, NHE1 (mouse): S707‑p, NHE1 (rat): S707‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

S796-p - NHE1 (human)
Orthologous residues
NHE1 (human): S796‑p, NHE1 (mouse): S801‑p, NHE1 (rat): S801‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)

S652-p - NHE1 (rat)
Orthologous residues
NHE1 (human): S648‑p, NHE1 (mouse): S652‑p, NHE1 (rat): S652‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  ARVM (myocyte)
 Cellular systems studied:  cell lines
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) activation of upstream enzyme, microscopy-colocalization


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