Curated Information
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Curated Information Page
PubMed Id: 18550772 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Fox EM, et al. (2008) Signal transducer and activator of transcription 5b, c-Src, and epidermal growth factor receptor signaling play integral roles in estrogen-stimulated proliferation of estrogen receptor-positive breast cancer cells. Mol Endocrinol 22, 1781-96 18550772
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y699-p - STAT5B (human) ▲
Orthologous residues
STAT5B (human): Y699‑p, STAT5B (mouse): Y699‑p, STAT5B (rat): Y699‑p
Characterization
 Methods used to characterize site in vivo:  immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell), T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF EGFR (human) increase
PP2 EGF EGFR (human) inhibit treatment-induced increase
ICI 182,780 EGF EGFR (human) no effect upon treatment-induced increase
estrogen ER-alpha (human) increase
PP2 estrogen ER-alpha (human) inhibit treatment-induced increase
ICI 182,780 estrogen ER-alpha (human) inhibit treatment-induced increase
AG1478 estrogen ER-alpha (human) inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, altered

Y740-p - STAT5B (human) ▲
Orthologous residues
STAT5B (human): Y740‑p, STAT5B (mouse): Y739‑p, STAT5B (rat): Y739‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human

Y743-p - STAT5B (human) ▲
Orthologous residues
STAT5B (human): Y743‑p, STAT5B (mouse): Y742‑p, STAT5B (rat): Y742‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  breast cancer
 Relevant cell lines - cell types - tissues:  T47D (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human


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