Curated Information
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Curated Information Page
PubMed Id: 18701649 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Grenier AL, et al. (2008) Apoptosis-induced alkalinization by the Na+/H+ exchanger isoform 1 is mediated through phosphorylation of amino acids Ser726 and Ser729. Am J Physiol Cell Physiol 295, C883-96 18701649
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T718-p - NHE1 (human) ▲
Orthologous residues
NHE1 (human): T718‑p, NHE1 (mouse): T722‑p, NHE1 (rat): T722‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  AP-1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human

S723-p - NHE1 (human) ▲
Orthologous residues
NHE1 (human): S723‑p, NHE1 (mouse): S727‑p, NHE1 (rat): S727‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  AP-1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human

S726-p - NHE1 (human) ▲
Orthologous residues
NHE1 (human): S726‑p, NHE1 (mouse): S730‑p, NHE1 (rat): S730‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  AP-1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE p38-alpha (human) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PD169316 decrease
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  apoptosis, induced
 Comments:  regulates the apoptotic alkalinizing activity of NHE1

S729-p - NHE1 (human) ▲
Orthologous residues
NHE1 (human): S729‑p, NHE1 (mouse): S733‑p, NHE1 (rat): S733‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  AP-1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE p38-alpha (human) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PD169316 decrease
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  apoptosis, induced
 Comments:  regulates the apoptotic alkalinizing activity of NHE1


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