Curated Information
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Curated Information Page
PubMed Id: 9104825 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yamanashi Y, et al. (1997) Role of tyrosine phosphorylation of HS1 in B cell antigen receptor-mediated apoptosis. J Exp Med 185, 1387-92 9104825
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y378-p - HS1 (human)
Orthologous residues
HS1 (human): Y378‑p, HS1 (mouse): Y388‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  COS (fibroblast), CV1 (fibroblast), WEHI-231 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Syk (human) pharmacological activator of upstream enzyme, modification site within consensus motif, phospho-motif antibody, transfection of wild-type enzyme, activation of upstream enzyme, genetic transfer of inducible upstream enzyme kinase activation is co-transfection with Lyn
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
BCR-stimulated cell showed high level of phosphorylation
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  apoptosis, altered

Y397-p - HS1 (human)
Orthologous residues
HS1 (human): Y397‑p, HS1 (mouse): Y405‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  COS (fibroblast), CV1 (fibroblast), WEHI-231 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Syk (human) pharmacological activator of upstream enzyme, modification site within consensus motif, phospho-motif antibody, transfection of wild-type enzyme, activation of upstream enzyme, genetic transfer of inducible upstream enzyme kinase activation is co-transfection with Lyn
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
BCR-stimulated cell showed high level of phosphorylation
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  apoptosis, altered


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