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Orthologous residues
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PDGFRa (human): Y720‑p, PDGFRa (mouse): Y720‑p, PDGFRa (rat): Y719‑p
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Characterization
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Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphopeptide mapping
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Relevant cell lines - cell types - tissues:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
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Cellular systems studied:
cell lines
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Species studied:
mouse
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Downstream Regulation
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Effect of modification (function):
molecular association, regulation
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Modification regulates interactions with:
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Interacting molecule
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Interacting domains
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Effect
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Consequences (function)
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Consequences (process)
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Detection assays
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SHP-2 (human)
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Induces
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molecular association, regulation
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co-immunoprecipitation
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Comments:
Grb2 binds to the PDGFRalpha indirectly via tyrosine-phosphorylated SHP-2.
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