Curated Information
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Curated Information Page
PubMed Id: 10521483 
Jones N, et al. (1999) Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. J Biol Chem 274, 30896-905 10521483
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1100-p - TIE2 (mouse)
Orthologous residues
TIE2 (human): Y1102‑p, TIE2 (mouse): Y1100‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [TIE2 (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TIE2 (mouse) transfection of inactive enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (mouse) Induces activity, induced yeast two-hybrid, co-immunoprecipitation
Grb7 (mouse) Induces activity, induced yeast two-hybrid, co-immunoprecipitation
SHP-2 (mouse) Induces activity, induced yeast two-hybrid
Grb14 (mouse) Induces activity, induced yeast two-hybrid
Grb2 (mouse) Induces activity, induced yeast two-hybrid, co-immunoprecipitation


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