Curated Information
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Curated Information Page
PubMed Id: 9407116 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Warmuth M, et al. (1997) The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr. J Biol Chem 272, 33260-70 9407116
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Y177-p - Bcr (human)
Orthologous residues
Bcr (human): Y177‑p, Bcr (mouse): Y178‑p, Bcr (rat): Y178‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  32D (myeloid), COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Hck (human) Disrupts electrophoretic visualization, co-immunoprecipitation
Grb2 (human) Induces molecular association, regulation co-immunoprecipitation
 Comments:  Transfection of Bcr in 32D cells induces enzymatic activation of Hck and Lyn.


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