Curated Information
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Curated Information Page
PubMed Id: 9380408 
Mancini A, et al. (1997) Identification of a second Grb2 binding site in the v-Fms tyrosine kinase. Oncogene 15, 1565-72 9380408
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y697-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y699‑p, CSFR (mouse): Y697‑p, CSFR (rat): Y697‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (mouse) SH2 Induces yeast two-hybrid, pull-down assay

Y921-p - CSFR (mouse)
Orthologous residues
CSFR (human): Y923‑p, CSFR (mouse): Y921‑p, CSFR (rat): Y921‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CSFR (mouse)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell growth, altered, cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (mouse) SH2 Induces yeast two-hybrid, pull-down assay
 Comments: 


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