Curated Information

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Curated Information Page

PubMed Id: 15143188

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Feener EP, et al. (2004) Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol 24, 4968-78 15143188

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y221-p - JAK2 (mouse)

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Orthologous residues

JAK2 (human): Y221‑p, JAK2 (mouse): Y221‑p, JAK2 (rat): Y221‑p

Characterization

Methods used to characterize site in vivo: mass spectrometry, mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 293 (epithelial) [EpoR (human)], 293 (epithelial) [JAK2 (mouse)]

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
Epo		EpoR (human)		increase

Y570-p - JAK2 (mouse)

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