Curated Information
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Curated Information Page
PubMed Id: 15143188 
Feener EP, et al. (2004) Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. Mol Cell Biol 24, 4968-78 15143188
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y221-p - JAK2 (mouse)
Orthologous residues
JAK2 (human): Y221‑p, JAK2 (mouse): Y221‑p, JAK2 (rat): Y221‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial) [EPOR (human)], 293 (epithelial) [JAK2 (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Epo EPOR (human) increase

Y570-p - JAK2 (mouse)
Orthologous residues
JAK2 (human): Y570‑p, JAK2 (mouse): Y570‑p, JAK2 (rat): Y570‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial) [EPOR (human)], 293 (epithelial) [JAK2 (mouse)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Epo EPOR (human) increase


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