Curated Information
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Curated Information Page
PubMed Id: 15197225 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Fernandez-Capetillo O, Allis CD, Nussenzweig A (2004) Phosphorylation of histone H2B at DNA double-strand breaks. J Exp Med 199, 1671-7 15197225
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S15-p - H2B (mouse)
Orthologous residues
H2B (human): S15‑p, H2B (mouse): S15‑p, H2B (rat): S15‑p, H2B (cow): S14‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  MEF (fibroblast), T lymphocyte-thymus
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
laser treatment increase
z-DEVD-fmk ionizing radiation no effect upon treatment-induced increase
wortmannin ionizing radiation inhibit treatment-induced increase


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