Curated Information
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Curated Information Page
PubMed Id: 12154078 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Graeser R, et al. (2002) Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. J Cell Sci 115, 3479-90 12154078
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S12-p - CDK16 (human)
Orthologous residues
CDK16 (human): S12‑p, CDK16 iso2 (human): S86‑p, CDK16 (mouse): S12‑p, CDK16 (rat): S12‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast), HeLa (cervical), Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)

S110-p - CDK16 (human)
Orthologous residues
CDK16 (human): S110‑p, CDK16 iso2 (human): S184‑p, CDK16 (mouse): S110‑p, CDK16 (rat): S110‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast), HeLa (cervical), Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)

S119-p - CDK16 (human)
Orthologous residues
CDK16 (human): S119‑p, CDK16 iso2 (human): S193‑p, CDK16 (mouse): S119‑p, CDK16 (rat): S119‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast), HeLa (cervical), Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 gamma (human) Induces pull-down assay
14-3-3 beta (human) Induces co-immunoprecipitation
14-3-3 zeta (human) Induces pull-down assay

S153-p - CDK16 (human)
Orthologous residues
CDK16 (human): S153‑p, CDK16 iso2 (human): S227‑p, CDK16 (mouse): S153‑p, CDK16 (rat): S153‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  293 (epithelial), CHO (fibroblast) [EphB1 (human), transfection], COS (fibroblast), HeLa (cervical), Neuro-2A (neuron)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human, monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Effect of modification (process):  cytoskeletal reorganization


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