Curated Information
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Curated Information Page
PubMed Id: 15138294 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lin YH, et al. (2004) Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol 165, 421-32 15138294
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Y171-p - Lasp-1 (human)
Orthologous residues
Lasp‑1 (human): Y171‑p, Lasp‑1 (mouse): Y173‑p, Lasp‑1 (rat): Y173‑p, Lasp‑1 (rabbit): Y174‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  leukemia, chronic myelogenous leukemia
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), COS (fibroblast), K562 (erythroid)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Abl (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Abl (human) genetic knockout/knockin of upstream enzyme, pharmacological activator of upstream enzyme, co-immunoprecipitation, pharmacological inhibitor of upstream enzyme, transfection of wild-type enzyme, phospho-motif antibody, modification site within consensus motif
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Abl iso2 (human) increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  apoptosis, induced


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