Curated Information
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Curated Information Page
PubMed Id: 15133032 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Zhang L, et al. (2004) Interleukin-7 and transforming growth factor-beta play counter-regulatory roles in protein kinase C-delta-dependent control of fibroblast collagen synthesis in pulmonary fibrosis. J Biol Chem 279, 28315-9 15133032
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y313-p - PKCD (human)
Orthologous residues
PKCD (human): Y313‑p, PKCD (mouse): Y311‑p, PKCD iso2 (mouse): Y311‑p, PKCD (rat): Y311‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-lung
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta no change compared to control
IL-7 no change compared to control

T507-p - PKCD (human)
Orthologous residues
PKCD (human): T507‑p, PKCD (mouse): T505‑p, PKCD iso2 (mouse): T531‑p, PKCD (rat): T505‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-lung
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase pulmonary fibrosis fibroblasts
IL-7 TGF-beta inhibit treatment-induced increase pulmonary fibrosis fibroblasts
TGF-beta no change compared to control normal fibroblasts
IL-7 no change compared to control

S645-p - PKCD (human)
Orthologous residues
PKCD (human): S645‑p, PKCD (mouse): S643‑p, PKCD iso2 (mouse): S669‑p, PKCD (rat): S643‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  fibroblast-lung
 Cellular systems studied:  primary cultured cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase pulmonary fibrosis fibroblasts
IL-7 TGF-beta inhibit treatment-induced increase pulmonary fibrosis fibroblasts
TGF-beta no change compared to control normal fibroblasts
IL-7 no change compared to control


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