Curated Information
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Curated Information Page
PubMed Id: 15082798 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Miyata Y, Nishida E (2004) CK2 controls multiple protein kinases by phosphorylating a kinase-targeting molecular chaperone, Cdc37. Mol Cell Biol 24, 4065-74 15082798
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S13-p - CDC37 (rat)
Orthologous residues
CDC37 (human): S13‑p, CDC37 (mouse): S13‑p, CDC37 (rat): S13‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (rat)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK2A1 (rat) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TBB decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RAF1 (rat) Induces cell growth, altered, cell cycle regulation co-immunoprecipitation
MOK (human) Induces cell growth, altered, cell cycle regulation co-immunoprecipitation
ICK (human) Induces cell growth, altered, cell cycle regulation co-immunoprecipitation
Akt1 (rat) Induces cell growth, altered, cell cycle regulation co-immunoprecipitation
AurB (rat) Induces cell growth, altered, cell cycle regulation co-immunoprecipitation
MAK (human) Induces cell growth, altered, cell cycle regulation co-immunoprecipitation
CDK4 (human) Induces cell growth, altered, cell cycle regulation co-immunoprecipitation


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