Curated Information
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Curated Information Page
PubMed Id: 15166239 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hao JJ, Carey GB, Zhan X (2004) Syk-mediated tyrosine phosphorylation is required for the association of hematopoietic lineage cell-specific protein 1 with lipid rafts and B cell antigen receptor signalosome complex. J Biol Chem 279, 33413-20 15166239
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y388-p - HS1 (mouse)
Orthologous residues
HS1 (human): Y378‑p, HS1 (mouse): Y388‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte) [HS1 (mouse)], WEHI-231 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  intracellular localization

Y405-p - HS1 (mouse)
Orthologous residues
HS1 (human): Y397‑p, HS1 (mouse): Y405‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte) [HS1 (mouse)], WEHI-231 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  intracellular localization


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