Curated Information

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Curated Information Page

PubMed Id: 14990569

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Ouchi M, et al. (2004) BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem 279, 19643-8 14990569

S308-p - BRCA1 (human)

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Orthologous residues

BRCA1 (human): S308‑p, BRCA1 iso6 (human): ‑, BRCA1 (mouse): S305‑p, BRCA1 (rat): S306‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: MCF-7 (breast cell) [AurA (human)]

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	AurA (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	AurA (human)	inhibition of upstream enzyme, transfection of wild-type enzyme

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