Curated Information

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Curated Information Page

PubMed Id: 1708091

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Downing JR, Shurtleff SA, Sherr CJ (1991) Peptide antisera to human colony-stimulating factor 1 receptor detect ligand-induced conformational changes and a binding site for phosphatidylinositol 3-kinase. Mol Cell Biol 11, 2489-95 1708091

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y699-p - CSFR (human)

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Orthologous residues

CSFR (human): Y699‑p, CSFR (mouse): Y697‑p

Characterization

Methods used to characterize site in vivo: [32P] bio-synthetic labeling, phospho-antibody

Relevant cell lines - cell types - tissues: 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]

Cellular systems studied: cell lines

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
CSF-1				increase

Downstream Regulation

Effect of modification (function): molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
PIK3CB (human)		Induces			co-immunoprecipitation

Y708-p - CSFR (human)

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