|
Orthologous residues
|
|
EphB1 (human): Y594‑p, EphB1 (mouse): Y594‑p, EphB1 (rat): Y594‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
COS (fibroblast), HRMEC (endothelial), P19 (testicular)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human, monkey, mouse
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
ephrin B1
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
molecular association, regulation
|
|
Effect of modification (process):
cell adhesion, altered
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
Nck1 (human)
|
SH2
|
Induces
|
molecular association, regulation
|
cell adhesion, altered
|
co-immunoprecipitation, yeast two-hybrid
|
|
|
Comments:
JNK1 activation
|
