Curated Information
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Curated Information Page
PubMed Id: 9430661 
Stein E, et al. (1998) Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase. J Biol Chem 273, 1303-8 9430661
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y594-p - EphB1 (human)
Orthologous residues
EphB1 (human): Y594‑p, EphB1 (mouse): Y594‑p, EphB1 (rat): Y594‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast), HRMEC (endothelial), P19 (testicular)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ephrin B1 increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Nck1 (human) SH2 Induces molecular association, regulation cell adhesion, altered yeast two-hybrid, co-immunoprecipitation
 Comments:  JNK1 activation


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