|
Orthologous residues
|
|
Mena (human): S265‑p, Mena iso2 (human): S265‑p, Mena iso5 (human): S284‑p, Mena (mouse): S255‑p, Mena iso3 (mouse): S236‑p, Mena iso4 (mouse): S236‑p, Mena (rat): S258‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
neuron-'brain, hippocampus'
|
|
Cellular systems studied:
primary cultured cells
|
|
Species studied:
mouse
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
PKCA (human)
|
activation of upstream enzyme, pharmacological activator of upstream enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
forskolin
|
|
|
|
increase
|
|
|
netrin-1
|
|
|
|
increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
cell growth, altered, cytoskeletal reorganization
|
