Curated Information
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Curated Information Page
PubMed Id: 11956222 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Powell DW, et al. (2002) Identification of 14-3-3zeta as a protein kinase B/Akt substrate. J Biol Chem 277, 21639-42 11956222
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S58-p - 14-3-3 zeta (human)
Orthologous residues
14‑3‑3 zeta (human): S58‑p, 14‑3‑3 zeta (mouse): S58‑p, 14‑3‑3 zeta (rat): S58‑p, 14‑3‑3 zeta (sheep): S58‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Akt1 (human) transfection of inactive enzyme, transfection of constitutively active enzyme, co-immunoprecipitation, mutation in upstream enzyme recognition motif
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 zeta (human) Induces


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