Curated Information
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Curated Information Page
PubMed Id: 11877382 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Postigo A, et al. (2002) Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes Dev 16, 633-45 11877382
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y516-p - TrkC (human) ▲
Orthologous residues
TrkC (human): Y516‑p, TrkC iso2 (human): Y516‑p, TrkC (mouse): Y516‑p, TrkC (rat): Y516‑p, TrkC iso2 (rat): Y516‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cochlear', 'neuron, cortical'-brain, 3T3 (fibroblast)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
neurotrophin-3 increase
Downstream Regulation
 Effect of modification (process):  cell growth, altered

Y515-p - TrkB (mouse) ▲
Orthologous residues
TrkB (human): Y516‑p, TrkB iso4 (human): Y532‑p, TrkB (mouse): Y515‑p, TrkB iso2 (mouse): ‑, TrkB (rat): Y515‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cochlear', 'neuron, cortical'-brain, 3T3 (fibroblast)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TrkB (mouse) genetic knockout/knockin of upstream enzyme
 Comments:  in response to BDNF
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BDNF increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, phosphorylation
 Effect of modification (process):  cell growth, altered


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