|
Orthologous residues
|
|
ADAM15 (human): Y715‑p, ADAM15 (mouse): Y716‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
293T (epithelial), Jurkat (T lymphocyte), K562 (erythroid), THP1 (myeloid), U-937 (myeloid)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Hck (human)
|
genetic transfer of wild-type enzyme, genetic transfer of dominant-negative enzyme, genetic transfer of constitutively active upstream enzyme
|
|
|
KINASE
|
Hck (human)
|
genetic transfer of wild-type enzyme, genetic transfer of dominant-negative enzyme, genetic transfer of constitutively active upstream enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
phorbol ester
|
|
|
|
increase
|
|
|
phorbol ester
|
|
|
|
increase
|
|
|
