Dmitrieva NI, Bulavin DV, Fornace AJ, Burg MB (2002) Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase. Proc Natl Acad Sci U S A 99, 184-9 11756692

This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2015, 43:D512-20). To learn more about the scope of PhosphoSitePlus®, click here.

Click on the protein name to open the protein page, and on the RSD number to open the site page.

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T53-p - ATF-2 (mouse) ▲

Modsite: IVADQtPtPtRFLKN SwissProt Entrez-Gene Orthologous residues ATF‑2 (human): T71‑p, ATF‑2 (mouse): T53‑p, ATF‑2 (rat): T53‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'kidney, inner medulla', mIMCD-3 (epithelial) Cellular systems studied:  cell lines, primary cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes osmotic_stress increase SB202190 decrease SB202190 osmotic_stress inhibit treatment-induced increase

S139-p - H2AX (mouse) ▲

Modsite: GkKAsQAsQEy____ SwissProt Entrez-Gene Orthologous residues H2AX (human): S139‑p, H2AX (mouse): S139‑p, H2AX (rat): S139‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'kidney, inner medulla', mIMCD-3 (epithelial) Cellular systems studied:  cell lines, primary cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes ionizing_radiation increase osmotic_stress increase SB202190 osmotic_stress augment treatment-induced increase

T180-p - P38A (mouse) ▲

Modsite: RHtDDEMtGyVAtRW SwissProt Entrez-Gene Orthologous residues P38A (human): T180‑p, P38A iso2 (human): T180‑p, P38A (mouse): T180‑p, P38A iso3 (mouse): T180‑p, P38A (rat): T180‑p, P38A (salmonid): T181‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'kidney, inner medulla', mIMCD-3 (epithelial) Cellular systems studied:  cell lines, primary cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes osmotic_stress increase SB202190 osmotic_stress no effect upon treatment-induced increase

Y182-p - P38A (mouse) ▲

Modsite: tDDEMtGyVAtRWYR SwissProt Entrez-Gene Orthologous residues P38A (human): Y182‑p, P38A iso2 (human): Y182‑p, P38A (mouse): Y182‑p, P38A iso3 (mouse): Y182‑p, P38A (rat): Y182‑p, P38A (salmonid): Y183‑p Characterization Methods used to characterize site in vivo:  phospho-antibody, western blotting Relevant cell lines - cell types - tissues:  'kidney, inner medulla', mIMCD-3 (epithelial) Cellular systems studied:  cell lines, primary cells Species studied:  mouse Upstream Regulation Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes osmotic_stress increase SB202190 osmotic_stress no effect upon treatment-induced increase