Curated Information
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Curated Information Page
PubMed Id: 18079404 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Chapman RD, et al. (2007) Transcribing RNA polymerase II is phosphorylated at CTD residue serine-7. Science 318, 1780-2 18079404
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1616-p - POLR2A (human)
Orthologous residues
POLR2A (human): S1616‑p, POLR2A var1 (human): S1616‑p, POLR2A (mouse): S1616‑p, POLR2A (rat): S1616‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, peptide sequencing, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  Raji (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S1619-p - POLR2A (human)
Orthologous residues
POLR2A (human): S1619‑p, POLR2A var1 (human): S1619‑p, POLR2A (mouse): S1619‑p, POLR2A (rat): S1619‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, peptide sequencing, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  Raji (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human

S1621-p - POLR2A (human)
Orthologous residues
POLR2A (human): S1621‑p, POLR2A var1 (human): S1621‑p, POLR2A (mouse): S1621‑p, POLR2A (rat): S1621‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, immunoprecipitation, mutation of modification site, peptide sequencing, western blotting
 Disease tissue studied:  lymphoma, Burkitt's lymphoma
 Relevant cell lines - cell types - tissues:  Raji (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (process):  transcription, induced
 Comments:  transcription of small nuclear RNA genes


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