Curated Information
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Curated Information Page
PubMed Id: 17923095 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Hu H, et al. (2007) Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell 131, 160-73 17923095
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S849-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal, CA1 pyramidal'-brain
 Cellular systems studied:  primary cells, tissue
 Species studied:  mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
norepinephrine increase
propranolol norepinephrine inhibit treatment-induced increase
KN-93 norepinephrine inhibit treatment-induced increase
phentolamine norepinephrine no effect upon treatment-induced increase
fearful stimulus increase
propranolol fearful stimulus inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, receptor desensitization, altered, receptor recycling, altered
 Comments:  norepinephrine faciitates synaptic delivery of GluR1 receptors, long-term potentiation, and emotion enhanced learning though phosphorylation of GluR1

S863-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal, CA1 pyramidal'-brain
 Cellular systems studied:  primary cells, tissue
 Species studied:  mouse, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
norepinephrine increase
propranolol norepinephrine inhibit treatment-induced increase
KT5720 norepinephrine inhibit treatment-induced increase
phentolamine norepinephrine no effect upon treatment-induced increase
KN-93 norepinephrine no effect upon treatment-induced increase
fearful stimulus increase
propranolol fearful stimulus inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, receptor desensitization, altered, receptor recycling, altered
 Comments:  norepinephrine faciitates synaptic delivery of GluR1 receptors, long-term potentiation, and emotion enhanced learning though phosphorylation of GluR1


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