Curated Information
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Curated Information Page
PubMed Id: 18037880 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Stock JK, et al. (2007) Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol 9, 1428-35 18037880
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K5-m3 - H3 (mouse) ▲
Orthologous residues
H3 (human): K5‑m3, H3 (mouse): K5‑m3, H3 iso2 (mouse): K5‑m3, H3 iso3 (mouse): K5‑m3, H3 (rat): K5‑m3, H3 iso3 (rat): K5‑m3, H3 (pig): K5‑m3, H3 (chicken): K5‑m3, H3 (cow): K5‑m3
Characterization
 Relevant cell lines - cell types - tissues:  ES (stem)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Comments:  ChIP
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase bivalent chromatin domains

K10-a - H3 (mouse) ▲
Orthologous residues
H3 (human): K10‑a, H3 (mouse): K10‑a, H3 iso2 (mouse): K10‑a, H3 iso3 (mouse): K10‑a, H3 (rat): K10‑a, H3 iso3 (rat): K10‑a, H3 (pig): K10‑a, H3 (chicken): K10‑a, H3 (cow): K10‑a
Characterization
 Relevant cell lines - cell types - tissues:  ES (stem)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Comments:  ChIP
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
increase bivalent chromatin domains

K28-m3 - H3 (mouse) ▲
Orthologous residues
H3 (human): K28‑m3, H3 (mouse): K28‑m3, H3 iso2 (mouse): K28‑m3, H3 iso3 (mouse): K28‑m3, H3 (rat): K28‑m3, H3 iso3 (rat): K28‑m3, H3 (pig): K28‑m3, H3 (chicken): K28‑m3, H3 (cow): K28‑m3
Characterization
 Relevant cell lines - cell types - tissues:  ES (stem)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Comments:  ChIP
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
tamoxifen no change compared to control
increase bivalent chromatin domains

S1616-p - POLR2A (mouse) ▲
Orthologous residues
POLR2A (human): S1616‑p, POLR2A var1 (human): S1616‑p, POLR2A (mouse): S1616‑p, POLR2A (rat): S1616‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  ES (stem)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
flavopiridol decrease

S1619-p - POLR2A (mouse) ▲
Orthologous residues
POLR2A (human): S1619‑p, POLR2A var1 (human): S1619‑p, POLR2A (mouse): S1619‑p, POLR2A (rat): S1619‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  ES (stem)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
flavopiridol no change compared to control
tamoxifen decrease 48h treatment S5 POLR2A at promoter and coding region of bivalent genes
increase bivalent chromatin domains
Downstream Regulation
 Effect of modification (process):  transcription, altered
 Comments:  low level transcription of bivalent genes


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