Curated Information
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Curated Information Page
PubMed Id: 17947241 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Chichili GR, Rodgers W (2007) Clustering of membrane raft proteins by the actin cytoskeleton. J Biol Chem 282, 36682-91 17947241
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Y505-p - Lck (human)
Orthologous residues
Lck (human): Y505‑p, Lck (mouse): Y505‑p, Lck (rat): Y505‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Filipin decrease
latrunculin B decrease
latrunculin B Filipin augment treatment-induced decrease
Filipin no change compared to control
latrunculin B no change compared to control
latrunculin B Filipin no change compared to control


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