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Orthologous residues
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MELK (human): T478‑p, MELK (mouse): A470‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Relevant cell lines - cell types - tissues:
COS (fibroblast)
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Cellular systems studied:
cell lines
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Species studied:
monkey
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Downstream Regulation
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Effect of modification (function):
molecular association, regulation
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Effect of modification (process):
translation, altered
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Modification regulates interactions with:
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Interacting molecule
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Interacting domains
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Effect
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Consequences (function)
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Consequences (process)
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Detection assays
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NIPP-1 (human)
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Induces
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|
|
sequence-specific competitor, pull-down assay, yeast two-hybrid
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|
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Comments:
regulates translation = spliceosome assembly
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