Curated Information
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Curated Information Page
PubMed Id: 14699119 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Vulsteke V, et al. (2004) Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. J Biol Chem 279, 8642-7 14699119
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T478-p - MELK (human)
Orthologous residues
MELK (human): T478‑p, MELK (mouse): A470‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  COS (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  translation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NIPP-1 (human) Induces sequence-specific competitor, pull-down assay, yeast two-hybrid
 Comments:  regulates translation = spliceosome assembly


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