Curated Information
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PubMed Id: 14741103 
Tanaka T, et al. (2004) Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration. Neuron 41, 215-27 14741103
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S297-p - Doublecortin (mouse)
Orthologous residues
Doublecortin (human): S378‑p, Doublecortin iso2 (human): S297‑p, Doublecortin (mouse): S297‑p, Doublecortin iso3 (mouse): S297‑p, Doublecortin (rat): S297‑p
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain, 293T (epithelial), COS (fibroblast)
 Cellular systems studied:  cell lines, primary cultured cells, tissue
 Species studied:  human, monkey, mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK5 (mouse)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK5 (mouse) co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (process):  cytoskeletal reorganization

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