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Orthologous residues
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|
doublecortin (human): S378‑p, doublecortin iso2 (human): S297‑p, doublecortin (mouse): S297‑p, doublecortin iso3 (mouse): S297‑p, doublecortin (rat): S297‑p
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Characterization
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|
Methods used to characterize site in vivo:
phospho-antibody, western blotting
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|
Relevant cell lines - cell types - tissues:
'neuron, cerebellar granule'-brain, 293T (epithelial), COS (fibroblast)
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Cellular systems studied:
cell lines, primary cultured cells, tissue
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Species studied:
human, monkey, mouse
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|
Enzymes shown to modify site in vitro:
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|
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Upstream Regulation
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|
Potential in vivo enzymes for site:
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|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
CDK5 (mouse)
|
co-immunoprecipitation, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
cytoskeletal reorganization
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