Curated Information
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Curated Information Page
PubMed Id: 16197368 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Wentworth JK, Pula G, Poole AW (2006) Vasodilator-stimulated phosphoprotein (VASP) is phosphorylated on Ser157 by protein kinase C-dependent and -independent mechanisms in thrombin-stimulated human platelets. Biochem J 393, 555-64 16197368
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S157-p - VASP (human)
Orthologous residues
VASP (human): S157‑p, VASP (mouse): S153‑p, VASP (rat): S154‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  platelet-blood
 Cellular systems studied:  primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PGE1 increase
cGMP analog increase
phorbol ester increase
bisindolylmaleimide phorbol ester inhibit treatment-induced increase
thrombin increase
bisindolylmaleimide thrombin inhibit treatment-induced increase
wortmannin thrombin no effect upon treatment-induced increase
Y27632 thrombin inhibit treatment-induced increase
bisindolylmaleimide Y27632 augment treatment-induced decrease
H1152 thrombin inhibit treatment-induced increase
bisindolylmaleimide H1152 augment treatment-induced decrease

S239-p - VASP (human)
Orthologous residues
VASP (human): S239‑p, VASP (mouse): S235‑p, VASP (rat): S236‑p
Characterization
 Methods used to characterize site in vivo electrophoretic mobility shift, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  platelet-blood
 Cellular systems studied:  primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PGE1 increase
cGMP analog increase
phorbol ester no change compared to control
thrombin no change compared to control


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