Curated Information
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Curated Information Page
PubMed Id: 18570922 
Salisbury E, et al. (2008) Ectopic expression of cyclin D3 corrects differentiation of DM1 myoblasts through activation of RNA CUG-binding protein, CUGBP1. Exp Cell Res 314, 2266-78 18570922
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S28-p - CELF1 (human)
Orthologous residues
CELF1 (human): S28‑p, CELF1 iso4 (human): S55‑p, CELF1 (mouse): S28‑p, CELF1 iso4 (mouse): S55‑p, CELF1 (rat): S28‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  myotonic dystrophy type1
 Relevant cell lines - cell types - tissues:  myoblast
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  translation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RNA Induces
 Comments:  increases CUGBP1 binding to cyclin D1 mRNA
Associated Diseases
Diseases: Alterations: Comments:
myotonic dystrophy type1 increased indirect evidence - Akt site, and Akt activity increased in DM1

S302-p - CELF1 (human)
Orthologous residues
CELF1 (human): S302‑p, CELF1 iso4 (human): S328‑p, CELF1 (mouse): S302‑p, CELF1 iso4 (mouse): S329‑p, CELF1 (rat): S303‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  C2C12 (myoblast), myoblast
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK6 (human)
KINASE CDK4 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  translation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RNA Induces
 Comments:  increases CUGBP1 binding to C/EBP beta and p21 mRNAs


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