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Orthologous residues
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CELF1 (human): S28‑p, CELF1 iso4 (human): S55‑p, CELF1 (mouse): S28‑p, CELF1 iso4 (mouse): S55‑p, CELF1 (rat): S28‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Disease tissue studied:
myotonic dystrophy type1
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Relevant cell lines - cell types - tissues:
myoblast
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Cellular systems studied:
primary cultured cells
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Species studied:
mouse
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Enzymes shown to modify site in vitro:
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Downstream Regulation
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Effect of modification (function):
molecular association, regulation
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Effect of modification (process):
translation, altered
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Modification regulates interactions with:
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Interacting molecule
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Interacting domains
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Effect
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Consequences (function)
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Consequences (process)
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Detection assays
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RNA
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Induces
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Comments:
increases CUGBP1 binding to cyclin D1 mRNA
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Associated Diseases
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Diseases:
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Alterations:
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Comments:
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myotonic dystrophy type1
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