Curated Information
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Curated Information Page
PubMed Id: 18657069 
Sorensen EB, Conner SD (2008) AAK1 regulates Numb function at an early step in clathrin-mediated endocytosis. Traffic 9, 1791-800 18657069
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T102-p - NUMB (human)
Orthologous residues
NUMB (human): T102‑p, NUMB iso2 (human): T102‑p, NUMB iso3 (human): T91‑p, NUMB (mouse): T102‑p, NUMB iso2 (mouse): T102‑p, NUMB (rat): T102‑p
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE AAK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AAK1 (human) modification site within consensus motif, co-immunoprecipitation
Downstream Regulation
 Effect of modification (function):  activity, induced, intracellular localization
 Effect of modification (process):  endocytosis, altered

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