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Orthologous residues
|
|
Kv4.2 (human): S552‑p, Kv4.2 (mouse): S552‑p, Kv4.2 (rat): S552‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
'neuron, hippocampal'
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
rat
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
PKACa (human)
|
pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
AMPA
|
|
|
|
increase
|
|
|
H-89
|
AMPA
|
|
|
inhibit treatment-induced increase
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
intracellular localization
|
|
Comments:
important for Kv4.2 internalization in hippocampal neurons
|
