Curated Information
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Curated Information Page
PubMed Id: 8456286 
Pongubala JM, et al. (1993) Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation. Science 259, 1622-5 8456286
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S148-p - PU.1 (mouse)
Orthologous residues
PU.1 (human): S146‑p, PU.1 (mouse): S148‑p, PU.1 (rat): S147‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
 Disease tissue studied:  plasmacytoma
 Relevant cell lines - cell types - tissues:  COS (fibroblast), S107 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
 Comments:  S194 cells
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (mouse)
Downstream Regulation
 Effect of modification (function):  activity, induced, molecular association, regulation
 Effect of modification (process):  transcription, induced
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
IRF4 (mouse) Induces electrophoretic visualization


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