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Orthologous residues
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|
PU.1 (human): S146‑p, PU.1 (mouse): S148‑p, PU.1 (rat): S147‑p
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Characterization
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Methods used to characterize site in vivo:
[32P] bio-synthetic labeling, mutation of modification site, phosphoamino acid analysis, phosphopeptide mapping
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Disease tissue studied:
plasmacytoma
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|
Relevant cell lines - cell types - tissues:
COS (fibroblast), S107 (B lymphocyte)
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|
Cellular systems studied:
cell lines
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|
Species studied:
monkey, mouse
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Comments:
S194 cells
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|
Enzymes shown to modify site in vitro:
|
|
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Downstream Regulation
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|
Effect of modification (function):
activation, molecular association, regulation
|
|
Effect of modification (process):
transcription, altered
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|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
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Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
IRF4 (mouse)
|
|
Induces
|
|
|
electrophoretic visualization
|
|
