Curated Information
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Curated Information Page
PubMed Id: 14970204 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Oh JS, Manzerra P, Kennedy MB (2004) Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II. J Biol Chem 279, 17980-8 14970204
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S780-p - SynGAP (rat) ▲
Orthologous residues
SynGAP (human): S780‑p, SynGAP iso2 (human): S780‑p, SynGAP (mouse): S780‑p, SynGAP (rat): S780‑p, SynGAP iso3 (rat): S721‑p, SynGAP iso5 (rat): S663‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, peptide sequencing, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical', 'neuron, cortical'-brain, HI-5
 Cellular systems studied:  cell lines, primary cells
 Species studied:  insect, mouse, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CaMK2-alpha (rat)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA increase
Downstream Regulation
 Effect of modification (function):  activation

S1073-p - SynGAP (rat) ▲
Orthologous residues
SynGAP (human): S1073‑p, SynGAP iso2 (human): S1073‑p, SynGAP (mouse): S1070‑p, SynGAP (rat): S1073‑p, SynGAP iso3 (rat): S1014‑p, SynGAP iso5 (rat): S956‑p

S1114-p - SynGAP (rat) ▲
Orthologous residues
SynGAP (human): S1114‑p, SynGAP iso2 (human): S1114‑p, SynGAP (mouse): S1111‑p, SynGAP (rat): S1114‑p, SynGAP iso3 (rat): S1055‑p, SynGAP iso5 (rat): S997‑p

S1138-p - SynGAP (rat) ▲
Orthologous residues
SynGAP (human): S1138‑p, SynGAP iso2 (human): S1138‑p, SynGAP (mouse): S1135‑p, SynGAP (rat): S1138‑p, SynGAP iso3 (rat): S1079‑p, SynGAP iso5 (rat): S1021‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, peptide sequencing, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical', 'neuron, cortical'-brain, HI-5
 Cellular systems studied:  cell lines, primary cells
 Species studied:  insect, mouse, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CaMK2-alpha (rat)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NMDA increase
Downstream Regulation
 Effect of modification (function):  activation


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