Curated Information
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Curated Information Page
PubMed Id: 18698806 
Amanchy R, et al. (2008) Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays. J Proteome Res 7, 3900-10 18698806
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y152-p - AKAP8 (human)
Orthologous residues
AKAP8 (human): Y152‑p, AKAP8 (mouse): Y152‑p, AKAP8 (rat): Y152‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y92-p - ARS2 (human)
Orthologous residues
ARS2 (human): Y92‑p, ARS2 iso3 (human): Y92‑p, ARS2 (mouse): Y92‑p, ARS2 (rat): Y92‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y175-p - ARS2 (human)
Orthologous residues
ARS2 (human): Y175‑p, ARS2 iso3 (human): Y175‑p, ARS2 (mouse): Y175‑p, ARS2 (rat): Y175‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y798-p - ARS2 (human)
Orthologous residues
ARS2 (human): Y798‑p, ARS2 iso3 (human): Y797‑p, ARS2 (mouse): Y797‑p, ARS2 (rat): Y692‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y836-p - ARS2 (human)
Orthologous residues
ARS2 (human): Y836‑p, ARS2 iso3 (human): Y835‑p, ARS2 (mouse): Y835‑p, ARS2 (rat): Y723‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y744-p - ataxin-2L (human)
Orthologous residues
ataxin‑2L (human): Y744‑p, ataxin‑2L iso2 (human): Y744‑p, ataxin‑2L (mouse): Y747‑p, ataxin‑2L iso2 (mouse): Y741‑p, ataxin‑2L (rat): Y741‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y80-p - BCLAF1 (human)
Orthologous residues
BCLAF1 (human): Y80‑p, BCLAF1 iso3 (human): Y78‑p, BCLAF1 iso4 (human): Y80‑p, BCLAF1 (mouse): Y80‑p, BCLAF1 (rat): Y80‑p, BCLAF1 iso3 (rat): Y221‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y81-p - BCLAF1 (human)
Orthologous residues
BCLAF1 (human): Y81‑p, BCLAF1 iso3 (human): Y79‑p, BCLAF1 iso4 (human): Y81‑p, BCLAF1 (mouse): Y81‑p, BCLAF1 (rat): Y81‑p, BCLAF1 iso3 (rat): Y222‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y93-p - BCLAF1 (human)
Orthologous residues
BCLAF1 (human): Y93‑p, BCLAF1 iso3 (human): Y91‑p, BCLAF1 iso4 (human): Y93‑p, BCLAF1 (mouse): Y93‑p, BCLAF1 (rat): Y93‑p, BCLAF1 iso3 (rat): Y234‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y150-p - BCLAF1 (human)
Orthologous residues
BCLAF1 (human): Y150‑p, BCLAF1 iso3 (human): Y148‑p, BCLAF1 iso4 (human): Y150‑p, BCLAF1 (mouse): Y150‑p, BCLAF1 (rat): Y150‑p, BCLAF1 iso3 (rat): Y291‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y284-p - BCLAF1 (human)
Orthologous residues
BCLAF1 (human): Y284‑p, BCLAF1 iso3 (human): Y282‑p, BCLAF1 iso4 (human): Y284‑p, BCLAF1 (mouse): Y283‑p, BCLAF1 (rat): Y283‑p, BCLAF1 iso3 (rat): Y424‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y408-p - BCLAF1 (human)
Orthologous residues
BCLAF1 (human): Y408‑p, BCLAF1 iso3 (human): Y406‑p, BCLAF1 iso4 (human): , BCLAF1 (mouse): Y406‑p, BCLAF1 (rat): Y408‑p, BCLAF1 iso3 (rat): Y549‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y12-p - calponin 2 (human)
Orthologous residues
calponin 2 (human): Y12‑p, calponin 2 (mouse): Y12‑p, calponin 2 (rat): Y12‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme

Y10-p - calponin 3 (human)
Orthologous residues
calponin 3 (human): Y10‑p, calponin 3 (mouse): Y10‑p, calponin 3 (rat): Y10‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme

Y334-p - Cortactin (human)
Orthologous residues
Cortactin (human): Y334‑p, Cortactin iso3 (human): Y297‑p, Cortactin (mouse): Y334‑p, Cortactin (rat): Y297‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme

Y278-p - EWS (human)
Orthologous residues
EWS (human): Y278‑p, EWS iso4 (human): Y278‑p, EWS (mouse): Y278‑p, EWS (rat): Y278‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme

Y58-p - FBP1 (human)
Orthologous residues
FBP1 (human): Y58‑p, FBP1 iso2 (human): Y58‑p, FBP1 iso3 (human): Y58‑p, FBP1 (mouse): Y54‑p, FBP1 (rat): Y54‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme

Y268-p - FBP1 (human)
Orthologous residues
FBP1 (human): Y268‑p, FBP1 iso2 (human): Y267‑p, FBP1 iso3 (human): Y289‑p, FBP1 (mouse): Y264‑p, FBP1 (rat): Y263‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y625-p - FBP1 (human)
Orthologous residues
FBP1 (human): Y625‑p, FBP1 iso2 (human): Y624‑p, FBP1 iso3 (human): Y646‑p, FBP1 (mouse): Y621‑p, FBP1 (rat): Y620‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y110-p - FIP1L1 (human)
Orthologous residues
FIP1L1 (human): Y110‑p, FIP1L1 iso3 (human): Y95‑p, FIP1L1 iso4 (human): Y95‑p, FIP1L1 (mouse): Y109‑p, FIP1L1 (rat): Y109‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme

Y133-p - G3BP-1 (human)
Orthologous residues
G3BP‑1 (human): Y133‑p, G3BP‑1 (mouse): Y133‑p, G3BP‑1 (rat): Y133‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y72-p - hnRNP K (human)
Orthologous residues
hnRNP K (human): Y72‑p, hnRNP K iso2 (human): Y72‑p, hnRNP K (mouse): Y72‑p, hnRNP K iso2 (mouse): Y72‑p, hnRNP K iso4 (mouse): Y72‑p, hnRNP K (rat): Y72‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial) [Src (human), transfection, Y527F constitutively active mutant]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme

Y317-p - KHSRP (human)
Orthologous residues
KHSRP (human): Y317‑p, KHSRP (mouse): Y318‑p, KHSRP (rat): Y318‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y583-p - KHSRP (human)
Orthologous residues
KHSRP (human): Y583‑p, KHSRP (mouse): Y584‑p, KHSRP (rat): Y584‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y688-p - KHSRP (human)
Orthologous residues
KHSRP (human): Y688‑p, KHSRP (mouse): Y689‑p, KHSRP (rat): Y689‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y597-p - PSF (human)
Orthologous residues
PSF (human): Y597‑p, PSF (mouse): Y589‑p, PSF (rat): Y589‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y691-p - PSF (human)
Orthologous residues
PSF (human): Y691‑p, PSF (mouse): Y683‑p, PSF (rat): Y683‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y16-p - RBM10 iso2 (human)
Orthologous residues
RBM10 (human): Y16‑p, RBM10 iso2 (human): Y16‑p, RBM10 iso3 (human): Y16‑p, RBM10 iso5 (human): Y81‑p, RBM10 (mouse): Y16‑p, RBM10 iso2 (mouse): Y16‑p, RBM10 (rat): Y16‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y434-p - RBM10 iso2 (human)
Orthologous residues
RBM10 (human): Y435‑p, RBM10 iso2 (human): Y434‑p, RBM10 iso3 (human): Y358‑p, RBM10 iso5 (human): Y500‑p, RBM10 (mouse): Y435‑p, RBM10 iso2 (mouse): Y358‑p, RBM10 (rat): Y358‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y905-p - RBM10 iso2 (human)
Orthologous residues
RBM10 (human): Y906‑p, RBM10 iso2 (human): Y905‑p, RBM10 iso3 (human): Y829‑p, RBM10 iso5 (human): Y971‑p, RBM10 (mouse): Y906‑p, RBM10 iso2 (mouse): Y829‑p, RBM10 (rat): Y828‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y379-p - SF3B2 (human)
Orthologous residues
SF3B2 (human): Y379‑p, SF3B2 (mouse): Y362‑p, SF3B2 (rat): Y362‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y592-p - SF3B2 (human)
Orthologous residues
SF3B2 (human): Y592‑p, SF3B2 (mouse): Y575‑p, SF3B2 (rat): Y575‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y33-p - TFG (human)
Orthologous residues
TFG (human): Y33‑p, TFG (mouse): Y33‑p, TFG (rat): Y33‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y247-p - TFG (human)
Orthologous residues
TFG (human): Y247‑p, TFG (mouse): Y247‑p, TFG (rat): Y248‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y68-p - Trap150 (human)
Orthologous residues
Trap150 (human): Y68‑p, Trap150 (mouse): Y68‑p, Trap150 (rat): Y68‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y107-p - Trap150 (human)
Orthologous residues
Trap150 (human): Y107‑p, Trap150 (mouse): Y107‑p, Trap150 (rat): Y107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y118-p - Trap150 (human)
Orthologous residues
Trap150 (human): Y118‑p, Trap150 (mouse): Y118‑p, Trap150 (rat): Y118‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y344-p - Trap150 (human)
Orthologous residues
Trap150 (human): Y344‑p, Trap150 (mouse): Y344‑p, Trap150 (rat): Y344‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y158-p - ZC3H4 (human)
Orthologous residues
ZC3H4 (human): Y158‑p, ZC3H4 (mouse): Y158‑p, ZC3H4 (rat): Y158‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y247-p - ZC3H4 (human)
Orthologous residues
ZC3H4 (human): Y247‑p, ZC3H4 (mouse): Y247‑p, ZC3H4 (rat): Y247‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)

Y1218-p - ZC3H4 (human)
Orthologous residues
ZC3H4 (human): Y1218‑p, ZC3H4 (mouse): Y1219‑p, ZC3H4 (rat): Y1136‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)


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