Curated Information
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Curated Information Page
PubMed Id: 14623872 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Alonso A, et al. (2004) Lck dephosphorylation at Tyr-394 and inhibition of T cell antigen receptor signaling by Yersinia phosphatase YopH. J Biol Chem 279, 4922-8 14623872
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Y394-p - Lck (human)
Orthologous residues
Lck (human): Y394‑p, Lck (mouse): Y394‑p, Lck (rat): Y394‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen, Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE yopH (bacteria) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced


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