Curated Information
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Curated Information Page
PubMed Id: 24163442 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Miteva YV, Cristea IM (2014) A Proteomic Perspective of Sirtuin 6 (SIRT6) Phosphorylation and Interactions and Their Dependence on Its Catalytic Activity. Mol Cell Proteomics 13, 168-83 24163442
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S10-p - SIRT6 (human)
Orthologous residues
SIRT6 (human): S10‑p, SIRT6 (mouse): S10‑p, SIRT6 (rat): S10‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

T294-p - SIRT6 (human)
Orthologous residues
SIRT6 (human): T294‑p, SIRT6 (mouse): A294‑p, SIRT6 (rat): A294‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S303-p - SIRT6 (human)
Orthologous residues
SIRT6 (human): S303‑p, SIRT6 (mouse): , SIRT6 (rat):
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S330-p - SIRT6 (human)
Orthologous residues
SIRT6 (human): S330‑p, SIRT6 (mouse): , SIRT6 (rat):
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S338-p - SIRT6 (human)
Orthologous residues
SIRT6 (human): S338‑p, SIRT6 (mouse): S317‑p, SIRT6 (rat): S313‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mass spectrometry, mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NUP85 (human) Induces intracellular localization co-immunoprecipitation
NUP88 (human) Induces intracellular localization co-immunoprecipitation
NUP35 (human) Induces intracellular localization co-immunoprecipitation
NUP214 (human) Induces intracellular localization co-immunoprecipitation
NUP155 (human) Induces intracellular localization co-immunoprecipitation
 Comments:  affects interactions and, indirectly, localization in the nucleoplasm


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