Curated Information
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PubMed Id: 14722116 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Koonpaew S, Janssen E, Zhu M, Zhang W (2004) The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. J Biol Chem 279, 11229-35 14722116
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y136-p - LAB (human)
Orthologous residues
LAB (human): Y136‑p, LAB (mouse): Y139‑p, LAB (rat): Y140‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  A20 (B lymphocyte), Jurkat (T lymphocyte), T lymphocyte-thymus
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgG increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (mouse) Induces co-immunoprecipitation

Y193-p - LAB (human)
Orthologous residues
LAB (human): Y193‑p, LAB (mouse): Y160‑p, LAB (rat): Y161‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  A20 (B lymphocyte), Jurkat (T lymphocyte), T lymphocyte-thymus
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgG increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (mouse) Induces co-immunoprecipitation

Y233-p - LAB (human)
Orthologous residues
LAB (human): Y233‑p, LAB (mouse): Y192‑p, LAB (rat): Y193‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  A20 (B lymphocyte), Jurkat (T lymphocyte), T lymphocyte-thymus
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgG increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell differentiation, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (mouse) Induces co-immunoprecipitation


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